Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hoffmann-La Roche
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Moderate to severe RA for at least 6 months
Positive serum rheumatoid factor (\>/= 20 international units per milliliter)
Current treatment with RA on an outpatient basis
Treatment failure with one disease modifying anti-rheumatic drug (DMARD) or biologic, but have not failed more than six of these agents including methotrexate
Current treatment with methotrexate for at least 12 weeks, at a stable dose
Use of highly effective contraception.
You may not be if
Rheumatic autoimmune disease or inflammatory joint disease, other than RA
Concurrent treatment with any disease-modifying anti-rheumatic drug (DMARD) (other than methotrexate) or any anti-tumor necrosis factor (TNF) -alfa or other biologic therapy
Treatment with any other investigational drug within 4 weeks of screening
Previous treatment with cell-depleting therapies, IV gamma-globulin, intra-articular or parenteral corticosteroids, and receipt of live/attenuated vaccine prior to screening
Previous treatment with rituximab or any other anti-cluster of differentiation 20 (CD20) agent
History of severe allergic or anaphylactic reactions to humanized monoclonal antibodies
Known active bacterial, viral or fungal infections
History of active tuberculosis and primary or secondary immunodeficiency
History of concomitant diseases such as cardiovascular disease, nervous system, pulmonary disease, renal, hepatic, endocrine or gastrointestinal disorders
