Study of the Efficacy and Safety of Intravitreal (IVT) Aflibercept for the Improvement of Moderately Severe to Severe Nonproliferative Diabetic Retinopathy (NPDR)

Exclusion Criteria

• •1. Presence of diabetic macular edema (DME) threatening the center of the macula in the study eye
• •2. Evidence of retinal neovascularization on clinical examination or Fluorescein Angiography (FA)
• •3. Any prior focal or grid laser photocoagulation or any prior PRP in the study eye
• •4. Any prior systemic anti-vascular endothelial growth factor (VEGF) treatment or intravitreal (IVT) anti-VEGF treatment in the study eye
• •5. Any prior intraocular steroid injection in the study eye
• •6. Current anterior segment neovascularization (ASNV), vitreous hemorrhage, or tractional retinal detachment visible at the screening assessments in the study eye