Frank Padberg, Prof. Dr.

CONTACT

Lead Sponsor

Ludwig-Maximilians - University of Munich

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

•Men and women 18-60 years of age.
•Capable and willing to provide informed consent.
•MDD: Primary ICD-10 diagnosis of Major Depression and a total HDRS-21 ≥15 and/or BDI ≥15 at the screening visit; no antidepressant medication and stable medication ≥4 days before study onset and during study period.
•SCZ: Primary ICD10 diagnosis of Schizophrenia and a stable antipsychotic medication ≥1 weeks before study onset and during study period.

•Contraindications for brain stimulation, such as history of brain surgery or severe brain injury, as well as contraindications for MRI, such as metallic implants, any other non-MR safe implants, or claustrophobia.
•Investigators, site personnel directly affiliated with this study, and their immediate families (immediate family is defined as a spouse, parent, child or sibling, whether by birth or legal adoption).
•Acute risk for suicide (MADRS, item 10 score of \>4 or as assessed by the C-SSRS, agree to item 4 and/or agree to item 5).
•Treatment with electroconvulsive therapy in the present episode.
•Treatment with deep brain stimulation or vagus nerve stimulation and/or any other intracranial implants (clips, cochlear implants).
•Any other relevant psychiatric axis-I- and/or axis-II-disorder.
•Any relevant instable medical condition.
•Pregnancy.