Healing Hearts and Mending Minds in Older Adults Living With HIV

Exclusion Criteria

• •Non sedentary (defined as engaging in \> 30 minutes of moderately strenuous exercise 3 times or more a week)
• •Medical or physical condition that would preclude participation in the exercise component of the study (e.g., severe arthritis or mobility problems, lower extremity amputations, joint replacement(s), balance disorders, dizziness, dyspnea on exertion (DOE) with moderate exertion, difficulty walking one block, recent falls, obvious injury to lower extremity, uncontrolled hypertension or diabetes, renal failure, blindness, or a history of angina with activity)
• •Ischemic changes or inappropriate BP changes on baseline exercise (modified Balke or Bruce) treadmill test
• •Presence of current opportunistic infection
• •Any terminal illness
• •Regular use of anti-inflammatory medications such as non-steroidal anti-inflammatory agents excluding low dose aspirin
• •On anti-psychotics
• •On tricyclic antidepressants
• •On anti-depressants equal to the equivalent of more than 1 mg of Clonazepam
• •On Lithium
• •Women who are pregnant
• •Severe learning disabilities, intellectual disabilities, schizophrenia, bipolar, psychotic disorders to minimize confounding effects on neurocognitive data
• •Confounding neuro-medical conditions (e.g., active central nervous system (CNS) opportunistic infections, seizure disorders, head injury with loss of consciousness greater than 30 minutes, intracranial neoplasms, stroke with neurological or neuropsychiatric sequelae, and non-HIV-associated dementias)
• •Meet criteria for any Substance Use Disorder or Major Depression within 6 months of evaluation
• •Creatinine \> 2.5 within the past 6 months
• •Patient Health Questionnaire-2 (PHQ-2) score \> 4
• •Completed 8 years or less of school
• •Failed to pass post-consent test after three attempts
• •Two or more positive drug screen tests
• •Alcohol breathalyzer test result \> 0.03