Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?

Exclusion Criteria

• •Pregnant or lactating, participating in another study with an investigational drug within one month prior to screening
• •Using gabapentin, pregabalin, anti-convulsants, duloxetine, venlafaxine (SNRI), or tri-cyclic antidepressants
• •have a history of allergic, anaphylactic reaction, or severe systemic response to pregabalin or gabapentin
• •use corticosteroids chronically or during the month prior to surgery, or have a history of corneal disease (HSV or varicella zoster keratitis, prior corneal incisions (cataract surgery, radial keratotomy, LASIK), prior corneal ulcer).
• •patients with systemic co-morbidities that may confound DE such as HIV, sarcoidosis, graft-versus host disease or a collagen vascular disease.
• •Adults unable to consent
• •Individuals who are not yet adults (infants, children, teenagers)
• •Prisoners