Shorter Course Radiation for the Treatment of Breast Cancer That Has Spread to Lymph Nodes

Exclusion Criteria

• •1. patients \<18 years old
• •2. pregnant women
• •3. male patients
• •4. women with T4 disease, including inflammatory breast cancer
• •5. women who have declined or otherwise not received preceding surgery
• •6. women with positive margins after primary surgery
• •7. women with node-negative disease
• •8. women without histologic confirmation of nodal involvement
• •9. women more than 180 days out from primary breast surgery or adjuvant chemotherapy
• •10. patients with clinically detected or suspicious lymph node involvement not readily amenable to surgical treatment (≥cN2 disease)
• •11. patients with synchronous bilateral breast cancers
• •12. patients with prior ipsilateral thoracic or breast radiation
• •13. patients with distant metastatic disease (cM1) or a life expectancy of less than 5 years
• •14. active collagen vascular disease, specifically dermatomyositis with a CPK level above normal or with an active skin rash, systemic lupus erythematosus, or scleroderma.
• •15. other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up.
• •16. patients with psychiatric or addictive disorders or other conditions that, in the opinion of the Investigator, would preclude the patient from meeting the study requirements.
• •17. patients with a separate non-cutaneous cancer diagnosis for which the patient has not been without evidence of disease for at least 5 years.
• •Note: women \<50 years of age, women who received chemotherapy, pN0 (i+ or mol+), and large-breasted women are eligible for enrollment.