High risk proliferative diabetic retinopathy

Cataract surgery within 3 months of Baseline, or any other previous intraocular surgery

Uncontrolled glaucoma

Current or history of ocular disease in the study eye other than DME

Major illness or major surgical procedure within 1 month prior to Day 1

Uncontrolled blood pressure

Glycosylated hemoglobin (HbA1c) greater than (\>) 12 percent (%) at screening

Untreated diabetes mellitus or initiation of oral anti-diabetic medication or insulin within 4 months prior to Day 1

A Study of Faricimab (RO6867461) in Participants With Center-Involving Diabetic Macular Edema