Neuroimaging Predictors of Relapse During Treatment for Opiate Dependence

Exclusion Criteria

• •current methadone maintenance treatment program participation
• •medically necessary prescription opiate treatment (e.g., for chronic pain)
• •current criteria for a DSM-V diagnosis of substance dependence for sedative or hypnotic drugs, alcohol, stimulants, cocaine, inhalants, hallucinogens
• •diagnosis of organic brain disorder, bipolar disorder, schizophrenia, schizo-affective, schizophreniform or paranoid disorder
• •current suicidality on the Modified Scale for Suicidal Ideation
• •evidence of neuropsychological dysfunction as assessed by the study physician with confirmation with the Folstein Mini-Mental Status Examination•
• •anticipated major painful event (significant surgical procedure) in the coming 4 months
• •probation or parole requirements or an upcoming move that might interfere with protocol participation
• •history of allergic reaction to buprenorphine or naloxone
• •currently pregnant or planning to become pregnant in the next 4 months
• •history of neurological disorder (e.g., epilepsy, stroke, brain injury)
• •impaired uncorrected vision
• •FMRI contraindications (e.g., claustrophobia, specific metallic implants and injuries)