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Sleep deprivation is known to affect brain function but is often ignored in the sickest patients including those in the intensive care unit after major surgery. In these patients, the levels of melatonin can also be altered. Melatonin is a hormone secreted in the brain that maintains the body's sleep-wake, or circadian, cycle. The investigators want to test whether improving sleep quality affects the risk of developing confusion (delirium) in patients having clot removed from their lung (open heart surgery). In order to improve sleep quality, the investigators will conduct a study of Ramelteon, a medication that mimics the activity of melatonin and measure its effects on levels of melatonin and monitor sleep.
Age
18 - 100 years
Sex
ALL
Healthy Volunteers
No
Start Date
February 1, 2016
Primary Completion Date
December 31, 2017
Completion Date
December 1, 2022
Last Updated
February 8, 2022
120
ACTUAL participants
Ramelteon
DRUG
Placebo
DRUG
Lead Sponsor
University of California, San Diego
NCT07357389
NCT05837039
NCT07323485
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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