Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Three-times Weekly Dosing of GSK1278863 in Hemodialysis-dependent Subjects With Anemia Associated With Chronic Kidney Disease Who Are Switched From a Stable Dose of an Erythropoiesis-stimulating Agent

Exclusion Criteria

• •Dialysis modality: Planned change from HD to peritoneal dialysis within the study time period.
• •Renal transplant: Planned for living-related kidney transplant.
• •High ESA dose: An epoetin dose of \>=360 international unit (IU)/kilogram (kg)/week IV or \>=250 IU/kg/week subcutaneous (SC) or darbepoetin dose of \>=1.8 microgram (mcg)/kg/week IV or SC or methoxy PEG-epoetin beta dose of \>= 2.2 mcg/kg/week within the prior 8 weeks through Day 1 (randomization).
• •Administration of methoxy PEG-epoetin beta within the prior 4 weeks through Day 1 (randomization).
• •Myocardial infarction or acute coronary syndrome: Within the 8 weeks prior to Screening through Day 1 (randomization).
• •Stroke or transient ischemic attack: Within 8 weeks prior to Screening though Day 1 (randomization).
• •Heart failure: Class IV heart failure, as defined by the New York Heart Association (NYHA) functional classification system diagnosed prior to Screening through Day 1 (randomization).
• •Correction of Q-T Interval using Bazett's formula (QTcB): QTcB \>500 millisecond (msec) or QTcB \>530 msec in subjects with Bundle Branch Block. There is no correction of Q-T Interval (QTc) exclusion for subjects with a predominantly paced rhythm.
• •Inflammatory disease: Active chronic inflammatory disease that could impact erythropoiesis (e.g., scleroderma, systemic lupus erythematosis, rheumatoid arthritis, celiac disease) diagnosed prior to Screening through Day 1 (randomization).
• •Hematological disease: Any hematological disease including those affecting platelets, white or red blood cells (e.g., sickle cell anemia, myelodysplastic syndromes, hematological malignancy, myeloma, hemolytic anemia and thalassemia), coagulation disorders (e.g., antiphospholipid syndrome, Protein C or S deficiency), or any other cause of anemia of chronic disease other than renal disease diagnosed prior to Screening though Day 1 (randomization).
• •Liver disease: Current liver disease, known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones) or evidence at Screening of abnormal liver function tests \[alanine transaminase (ALT) or aspartate transaminase (AST) \>2x upper limit of normal (ULN) or total bilirubin \>1.5xULN\]; or other hepatic abnormalities that in the opinion of the investigator would preclude the subject from participating in the study.
• •NOTE: Those with Hepatitis B or Hepatitis C are eligible provided these exclusions are not met.
• •Major surgery: Major surgery (excluding vascular access surgery) within the 8 weeks prior to Screening, during the Screening phase, or planned during the study.
• •Transfusion: Blood transfusion within the 8 weeks prior to Screening, during the Screening phase or an anticipated need for blood transfusion during the study.
• •Gastrointestinal (GI) Bleeding: Evidence of actively bleeding peptic, duodenal, or esophageal ulcer disease OR clinically significant GI bleeding within the 8 weeks prior to Screening through Day 1 (randomization).
• •Acute Infection: Clinical evidence of acute infection or history of infection requiring IV antibiotic therapy within the 4 weeks prior to Screening through Day 1 (randomization). NOTE: IV antibiotics as prophylaxis are allowed.
• •Malignancy: History of malignancy within the two years prior to randomization or currently receiving treatment for cancer, or has a known \>=4 centimeter complex kidney cyst (i.e. Bosniak Category II F, III of IV). NOTE: ONLY exception is squamous cell or basal cell carcinoma of the skin that has been definitively treated \>=8 weeks prior to Screening.
• •Severe allergic reactions: History of severe allergic or anaphylactic reactions or hypersensitivity to excipients in the investigational product
• •Drugs and supplements: Use of any prescription or non-prescription drugs or dietary supplements that are prohibited (as per protocol) from Screening until the Follow-up Visit.
• •Prior investigational product exposure: The Subject has participated in a clinical trial and has received an experimental investigational product within the prior 30 days from Screening through Day 1 (randomization).
• •Other conditions: Any other condition, clinical or laboratory abnormality, or examination finding that the investigator considers would put the subject at unacceptable risk, which may affect study compliance or prevent understanding of the aims or investigational procedures or possible consequences of the study.
• •Vitamin B12: At or below the lower limit of the reference range (may rescreen in a minimum of 8 weeks).
• •Folate: \<2.0 nanogram (ng) per millilitre (mL) (4.5 nanomole/liter \[L\]) (may rescreen in a minimum of 4 weeks).
• •Ferritin: \<100 ng/mL (\<100 mcg/L).
• •Transferrin saturation (TSAT): \<20 percent.