Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
GlaxoSmithKline
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
18 to 80 years of age inclusive
Historical diagnosis of type 2 diabetes mellitus (T2DM) (at least 3 months), experiencing inadequate glycemic control on current regimen of diet and exercise or on a stable maximal tolerated dose of metformin, maintained for approximately 8 weeks prior to screening.
HbA1c \>=7.0 percent (%) and \<=10%.
Hemoglobin \>=11 grams per deciliter (g/dL) (\>=110 grams per liter \[g/L\]) for males and \>=10 g/dL (\>=100 g/L) for females.
Body mass index \<=40 kilograms per squared meter (kg/m\^2)
Male or female
Able and willing to provide informed consent.
You may not be if
Type 1 diabetes mellitus
History of cancer that has not been in full remission for at least 3 years before screening. (A history of squamous cell or basal cell carcinoma of the skin or treated cervical intra-epithelial neoplasia I or II is allowed).
Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2.
History of acute or chronic pancreatitis.
History of thyroid dysfunction or an abnormal (i.e., outside the normal reference range) thyroid function test assessed by thyroid stimulating hormone at screening.
Severe gastroparesis, i.e., requiring regular therapy within 6 months before screening.
History of significant gastrointestinal (GI) surgery that in the opinion of the investigator is likely to significantly affect upper GI or pancreatic function
History of severe hypoglycemia unawareness
Diabetic complications or any other clinically significant abnormality .
Clinically significant Cardiovascular (CV) and/or cerebrovascular disease within 3 months before screening
QT interval corrected for heart rate according to Fridericia's formula (QTcF) \> 470 milliseconds (msec).
ALT \>2.5x upper limit of the normal range (ULN) or bilirubin \>1.5xULN (isolated bilirubin \>1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin \<35%).
Current active liver or biliary disease (with the exception of Gilbert's syndrome or asymptomatic gallstones or otherwise stable chronic liver disease per investigator assessment).
Estimated glomerular filtration rate (eGFR) \<=30 milliliter (mL)/minute (min)/1.73 squared meter (m\^2) (calculated using the Modification of Diet in Renal Disease \[MDRD\] formula) at screening.
Fasting triglyceride level \>750 milligrams per deciliter (mg/dL) at screening.
Hemoglobinopathy that may affect proper interpretation of HbA1c.
Medical or psychiatric disorders that would preclude effective participation in study.
Use of oral or systemically injected glucocorticoids within the 3 months before randomization or high likelihood of a requirement for prolonged treatment (\>1 week) in the 6 months following randomization.
Use of dipeptidyl peptidase-IV inhibitors within the 3 months before randomization.
History of alcohol or substance abuse within one year before screening.
Known allergy to albiglutide or any product components (including yeast and human albumin), any other glucagon-like peptide-1 (GLP-1) analogue, or other study medication's excipients OR other contraindications (per the prescribing information) for the use of potential study medications.
A positive pre-study drug/alcohol screen.
A positive test for human immunodeficiency virus (HIV) antibody.
The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
