Mitochondrial-related Platelet Transcript Expression Levels in Pre-diabetic Subjects Randomized to Metformin or Placebo

Exclusion Criteria

• •unwilling to accept treatment assignment by randomization
• •participation in another clinical research trial
• •history of myocardial infarction or stroke
• •significant arrhythmia (e.g. atrial fibrillation)
• •active thromboembolic disease
• •inflammatory bowel disease
• •serum creatinine levels greater than or equal to 1.5 mg/dL in males or greater than or equal to 1.4 mg/dL in females
• •known hypersensitivity to metformin hydrochloride or any of its components
• •acute or chronic metabolic acidosis
• •inability to participate in lifestyle modifications
• •pregnancy; other glucose-lowering or diabetic therapy
• •systemic glucocorticoids
• •prescription weight loss medications
• •or otherwise deemed unsuitable by study investigators (e.g. unable to complete follow-up visits, alcohol abuse, etc).