Disulfiram in Recurrent Glioblastoma

Exclusion Criteria

• •1. Earlier treatment for progression (e.g. "rescue therapy")
• •2. History of idiopathic seizure disorder, psychosis or schizophrenia.
• •3. History of uncontrolled hypertension (i.e. systolic BP \> 180 mmHg) and a diagnosis of congestive heart failure
• •4. Received radiotherapy within the 3 months before the diagnosis of progression .
• •5. Addiction to alcohol or drugs.
• •6. Pregnant and/or breastfeeding.
• •7. Women of childbearing potential who do not have negative pregnancy test not older than 14 days before enrollment.
• •8. History of active liver disease, including chronic active hepatitis, viral hepatitis (hepatitis B, C and CMV), cholestatic jaundice of any etiology or toxic hepatitis or inadequate hepatic function, defined as baseline ASAT and ALAT \> 2.5 X upper institutional limit and/or bilirubin \> 2.0 X upper institutional limit.
• •9. History of Wilson's disease or family member with Wilson's disease (unless excluded as a carrier by genetic test).
• •10. History of hemochromatosis or family member with hemochromatosis (unless excluded as a carrier by genetic test).
• •11. Nickel hypersensitivity (disulfiram mobilize nickel causing a brief increase in nickel concentrations before excretion. The initial increase may lead to hepatitis and predisposed patients).
• •12. Need for metronidazole, warfarin and/or theophylline medication (the metabolism may be influenced by disulfiram).
• •13. Patients who are taking medications metabolized by cytochrome P450 2E1, including chlorzoxazone or halothane and its derivatives (phenytoin, phenobarbital, chlordiazepoxide, imipramine, diazepam, isoniazid, metronidazole, warfarin, amitriptyline within 14 days prior to the first dose of disulfiram. Of note, lorazepam and oxazepam are not affected by the P450 system and are not contraindicated with disulfiram).
• •14. Unfit for participation for any other reason judged by the including physician.