Phase 1 Study of DS-6051b in Japanese Subjects With Advanced Solid Malignant Tumors

Exclusion Criteria

• •Previously had or currently has any of the following diseases:
• •Cardiac failure (NYHA Functional Classification ≥ Class III), myocardial infarction, cerebral infarction, unstable angina, arrhythmia requiring treatment, coronary/peripheral artery disease, pulmonary thrombosis, uncontrolled deep vein thrombosis, clinically severe thromboembolic event, or autoimmune disease requiring treatment.
• •Previously had or currently has clinically severe pulmonary disease (eg, interstitial pneumonia, pneumonitis, pulmonary fibrosis, radiation pneumonia).
• •Severe or uncontrolled concomitant disease.
• •Clinically active brain metastases or central nervous system tumor requiring steroid or anticonvulsant treatment.