Known hypersensitivity to estrogen and/or progestin therapy

Known or suspected premalignant or malignant disease

Undiagnosed abnormal genital bleeding

A history of or treatment for significant cardiovascular disease, congestive heart failure, or stroke

Active or known protein C, protein S, or antithrombin deficient, or other known thrombophilic disorders or thromboembolic events

Increased frequency/severity headaches with estrogen therapy

Smokes ≥ 15 cigarettes/day

A Safety and Efficacy Study of Estradiol Vaginal Capsule in Postmenopausal Women With Vulvovaginal Atrophy