Effect of Increased Positive End-expiratory Pressure on Intracranial Pressure in Different Respiratory Mechanic in Acute Respiratory Distress Syndrome

Exclusion Criteria

• •1. Hemodynamic instability requiring more than 10 μg/kg/min dopamine or more than 0.5 μg/kg/min norepinephrine;
• •2. ICP \> 25 mmHg;
• •3. Esophageal varices;
• •4. History of esophageal or gastric surgery;
• •5. Evidence of active air leak from the lung, including bronchopleural fistula, pneumothorax, pneumomediastinum, or existing chest tube;
• •6. History of chronic obstructive pulmonary disease.