Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
GlaxoSmithKline
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Between 18 and 65 years of age.
Healthy.
Subject is a nonsmoker.
Subject's body mass index (BMI) is \>=18 kilogram/meter square (kg/m\^2) and \<=30 kg/m\^2
Male or
Female
You may not be if
Alanine aminotransferase (ALT) \>1.5 x upper limit of normal range (ULN)
Bilirubin \>1.5xULN (isolated bilirubin \>1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin \<35 percent \[%\]).
Current or chronic history of liver disease, or known hepatic or biliary abnormalities
QT interval corrected for heart rate according to Fridericia's formula (QTcF) \> 450 millisecond (msec).
Systolic blood pressure is \>=140 millimeter of mercury (mmHg) at Screening;
Diastolic blood pressure is \>=90 mmHg at Screening;
Heart rate is \>100 beats/min at Screening.
estimated glomerular filtration rate (eGFR) \<=80 milliliter per minute per 1.73 meter square (mL/min/1.73 m\^2) (calculated using the Chronic Kidney Disease Epidemiology Collaboration \[CKD-EPI\] formula) at Screening.
Fasting triglyceride level \>300 milligram per deciliter (mg/dL) at Screening.
History of significant cardiovascular or pulmonary dysfunction prior to Screening.
History of thyroid dysfunction or an abnormal (i.e., outside the normal reference range) thyroid function test assessed by thyroid stimulating hormone at Screening.
History of gastrointestinal surgery that could influence gastric emptying (e.g., gastrectomy, gastric bypass).
History of pancreatitis.
Personal or family history of multiple endocrine neoplasia type 2.
Personal or family history of medullary carcinoma of the thyroid.
Unable to refrain from the use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days.
History of regular alcohol consumption within 6 months of the study.
Urinary cotinine levels indicative of smoking or history or regular use of tobacco- or nicotine-containing products within 3 months prior to screening.
History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy.
Subject has previously received any GLP-1 mimetic compound (eg., exenatide, liraglutide, lixisenatide, dulaglutide).
Presence of hepatitis B surface antigen (HBsAg), positive hepatitis C antibody test result at screening or within 3 months prior to first dose of study treatment.
A positive pre-study drug/alcohol screen.
A positive test for human immunodeficiency virus (HIV) antibody.
Subject has donated blood in excess of 500 mL within 56 days prior to dosing or intention of donating in the month after completing the study.
The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
Exposure to more than 4 new chemical entities within 12 months prior to the first dosing day
