The Approach Open Label Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Chylomicronemia Syndrome

Exclusion Criteria

• •Unwilling to comply with lifestyle requirements for the duration of the study.
• •Group 1 and 2:
• •Have any new condition or worsening of existing condition which in the opinion of the Investigator would make the participant unsuitable for enrollment, or could interfere with the participant participating in or completing the study.
• •Group 3:
• •Diabetes mellitus if newly diagnosed or if hemoglobin A1c (HbA1c)≥ 9.0%.
• •Active pancreatitis within 4 weeks of screening.
• •Acute Coronary Syndrome within 6 months of screening.
• •Major surgery within 3 months of screening.
• •Treatment with Glybera therapy within 2 years of screening.
• •Have any other conditions in the opinion of the investigator which could interfere with the participant participating in or completing the study.