microRNA of Human Epidermal Growth Factor Receptor 2 （HER2）Positive Patient Treated With Herceptin

Inclusion Criteria

• •1. The patients signed the written informed consent
• •2. female patient who is ≥ 18yrs,
• •3. HER2 positive: immunohistochemistry (+++) or FISH (+)
• •4. stage IV
• •5. the patients have no history of chemotherapy ,hormone therapy,radiotherapy or surgery after diagnosis of breast cancer
• •6. the result of patients' blood tests are as follow: WBC≥3.0×109/L; Plt≥100×109/L;AST/SGOT or ALT/AGPT≤tripple of normal upper limit; Creatinine\<double of the normal upper limit
• •7. ECOG scores are 0 or 1 .
• •8. The patient is able to take oral pills