Prospective Neurobehavioral Outcomes Follow-up in Primary CNS Lymphoma Patients Treated With Cranial Radiotherapy Combined With or Without MTX-based Chemotherapy According to the Multidisciplinary Treatment Guidelines Implemented at a Single Institute

Inclusion Criteria

• •All patients must have a histopathologic diagnosis of non-Hodgkin's lymphoma (NHL) by brain biopsy
• •A typical MRI/CT scan for primary CNS lymphoma is defined as the presence of hypo, iso, or hyperintense parenchymal contrast-enhancing (usually homogeneously) mass lesion(s)
• •Patients must have a normal or negative pre-treatment systemic evaluation including: i. A bone marrow aspirate and biopsy ii. CT scans of the chest, abdomen and pelvis iii. Patients must have adequate bone marrow reserve
• •Patients must be HIV-1 negative
• •Men and women of reproductive potential must agree to use an acceptable method of birth control during treatment and for six months after completion of treatment