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Keep this study
Lead
Institut Cancerologie de l'Ouest
About 5% of breast cancers are associated with the presence of a constitutional genetic alteration. Two genes are being studied: BRCA1 and BRCA2.
The national program for breast cancer screening target women 50 to 74 years but does not include women with significant risk factors. However in identifiable risk situations, breast cancer incidence is increased: and it affects 1 in 4 women with certain risk histological lesions and more than 1 in 2 women carrying a mutation in the BRCA1 or BRCA2 gene.
Studies have shown that the olfactomédine 4 (OLFM4) is highly overexpressed in tumors compared to healthy tissue. The OLFM4 might therefore be a marker for early detection of breast cancer. We wish to determine the positive predictive value of OLFM4 seric dosing of patients at risk with respect to imaging.
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Age \> or = 18 years
High risk women of breast cancer occurrence defined by the following criteria:
* Women carrying a genetic mutation BRCA1 or 2 or TP53, entering or already in screening breast IRM
* Women with a high probability of hereditary predisposition to breast cancer (20% risk at 70 years of breast cancer by BOADICEA model), assessed by the onco-geneticists
Information of the person and signing the informed consent
You may not be if
Women with a history of breast cancer or in situ
Person who is not affiliated to a social security scheme or beneficiary of such a regime
Clareo Health | Women at Risk of Breast Cancer and OLFM4
