Aged 18-50

Capable of storing food safely, willing to follow diet/eat provided food, and able to receive shipments at home or work

Meets 2010 criteria for McDonald MS;

Relapse or new lesion in previous 2 years

Expanded disability status score (EDSS) \< 6

Disease duration ≤15 years

Untreated or on stable on first-line MS therapy \[injectable\] for at least 6 months, with no anticipated changes in the next 10 weeks

Unchanged vitamin D dose or thyroid replacement dose (for those on it) with no anticipated changes or in supplement use for the next 10 weeks.

Non-regular smoker (average no more than 1 cigarette/day) for at least 2 months

Stable weight, by self report, for past 3 months (± 8 lbs)

Body mass index (BMI) \> 23 kg/m2

A Pilot Study of Intermittent Calorie Restriction in Multiple Sclerosis