Loading clinical trials...

Effect of Two Exercise Programs on Bone Strength and Architecture | Clinical Trials | Clareo Health

COMPLETEDNA

Effect of Two Exercise Programs on Bone Strength and Architecture

NCT02636530•University of Colorado, Denver

Summary

Bone responds according to the load placed on it. In this study, investigators want to know if exercise that loads the body in exercises, like walking or jogging (Ground Reaction Forces: GRF), affects bone differently than exercises that load the joints, like weight lifting (Joint Reaction Forces: JRF). Participants will exercise at least 3 times a week for 6 months. Measures of bone strength and mass, muscular strength, and aerobic fitness will be taken at the beginning and the end of the 6 month program. Period blood samples will be taken for future analysis of blood markers.

Eligibility

Age

60 - 75 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•non-smoker
•in generally good health
•not physically active (less than 60 minutes of purposeful exercise/week)
•able to travel to the exercise facility a minimum of 3 times/week

Exclusion Criteria

•use of glucocorticoids
•abnormal resting EKG
•angina and/or evidence of acute myocardial ischemia during a treadmill test
•resting blood pressure above 150 mmHg systolic of 90 mmHg diastolic
•anti-resorptive drug use in the last 2 years
•initiation of treatments that could impact bone metabolism (diuretics, hormones, bine anabolic agents) in the prior 6 months
•dual-energy x-ray absorptiometry (DXA) t-score \<+ -2.5 at the femoral neck and/or lumbar spine
•serum vitamin D concentration \<20 ng/mL
•uncontrolled thyroid disease
•any contraindications to regular exercise

Locations (2)

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Veteran's Affairs Eastern Colorado Healthcare System

Denver, Colorado, United States

Key Dates

Start Date

July 1, 2016

Primary Completion Date

December 1, 2021

Completion Date

December 1, 2021

Last Updated

January 11, 2022

Enrollment

ACTUAL participants

Conditions

Osteoporosis

Interventions

Ground Reaction Forces

BEHAVIORAL

Joint Reaction Forces

BEHAVIORAL

OsteoPorotic fracTure preventION System (OPTIONS) Research Study

NCT06731608

OsteoporosisLower Limb Fracture

View study

RECRUITINGPHASE4

Step-down Therapy After Long-term Osteoporosis Treatment

NCT07281586

Osteoporosis

View study

RECRUITING

Smart Wearable Device (gaitQ): Walk Better Project

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 11, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Effect of Two Exercise Programs on Bone Strength and Architecture

Inclusion Criteria

Exclusion Criteria

OsteoPorotic fracTure preventION System (OPTIONS) Research Study

Step-down Therapy After Long-term Osteoporosis Treatment

Smart Wearable Device (gaitQ): Walk Better Project

Automated Bone Age Estimation From Noncontrast Abdominal CT Using Deep Learning

Effect of Mechanical Loading and Bone Loss on Motor Neuron Activity-H-Reflex Relationship

Clinical Study to Estimate Bone Mineral Density With the POROUS Ultrasound Device