Treatment of Recently Acquired Hepatitis C With the 3D Regimen or G/P

Inclusion Criteria

• •Provision of written informed consent;
• •Male and female patients aged 18 years and over;
• •For Cohort One: willing to use two effective methods of contraception during the treatment period and 24 weeks post;
• •For Cohort Two and Three: If female and of childbearing potential, willing to use at least one effective method of contraception during the treatment period and 4 weeks post; women not of childbearing potential include those who are postmenopausal or permanently surgically sterile (no contraception is required for male participants);
• •For Cohort One, Two and Three: Females of child-bearing potential must have a negative pregnancy test at screening and immediately prior to first dose of study drugs;
• •HCV genotype 1 infection at screening (Cohort 1 only);
• •Detectable HCV RNA at screening (\>10,000 IU/ml), and in the opinion of the investigator is unlikely to demonstrate spontaneous viral clearance;
• •Absence of cirrhosis, as defined by one of the following:
• •* Liver biopsy within 24 months prior to or during screening demonstrating absence of cirrhosis (eg, METAVIR fibrosis score ≤ 3, Ishak fibrosis score ≤ 4); or
• •* FibroScan score \< 12.5 kPa within ≤ 6 months of screening or during screening period; or
• •Medically stable on the basis of physical examination, medical history and vital signs;
• •Adequate English to provide reliable responses to the study questionnaires;
• •Recently acquired HCV infection (estimated duration of infection ≤12 months) as defined by\*:
• •1. i) First anti-HCV Ab or HCV RNA positive within the previous 6 months and ii) Documented anti-HCV Ab negative within the 18 months prior to anti-HCV antibody positive result
• •OR
• •2. i) First anti-HCV Ab or HCV RNA positive within the previous 6 months and ii) Acute clinical hepatitis (jaundice or ALT\> 10 X ULN) within the previous 12 months prior to first positive HCV antibody or HCV RNA, with no other cause of acute hepatitis identifiable
• •OR
• •3. i) First anti-HCV Ab or HCV RNA positive within the previous 6 months and ii) Acute asymptomatic hepatitis (acute rise in ALT\> 5 X ULN) within the previous 12 months prior to first positive HCV antibody or HCV RNA and documented normal ALT within the previous 12 months with no othercause of acute hepatitis identifiable (In individuals with a previously high ALT, an acute rise to \>3.5 x their previous peak ALT in last 12 months is acceptable)
• •OR
• •4. For cases of recent HCV reinfection the following criteria are required: Documented prior HCV antibody positive with HCV RNA negative on at least 2 occasions 6 months apart AND new HCV RNA positive within the previous 6 months.
• •\* Estimated duration of infection based on midpoint between last antibody or RNA negative and first antibody or HCV RNA positive in the case of seroconversion and 6 weeks prior to date of maximum ALT in the case of acute hepatitis.
• •If co-infection with HIV is documented, the subject must meet the following criteria:
• •Cohort One:
• •On a stable qualifying ARV regimen for \>8 weeks prior to screening visit, with CD4 T cell count \>200 cells/mm3 and a plasma HIV RNA below the limit of detection.
• •Cohort Two:
• •On a stable qualifying ARV regimen for \>8 weeks prior to screening visit, with CD4 T cell count \>200 cells/mm3 and a plasma HIV RNA below the limit of detection.
• •OR
• •ARV naïve with CD4 T cell count \>500 cells/mm3