Two Different Schedules of Palbociclib + Second Line Endocrine Therapy in Estrogen Receptor Positive, HER2 Neg Advanced/Metastatic Breast Cancer

Premenopausal and postmenopausal women 18 years of age or older.

Histologically confirmed adenocarcinoma of the breast, with ER positive and HER2 negative status based on local testing on most recent pathological tumour specimen.

Patients must satisfy the following criteria for prior therapy:

* Progressed during treatment or within 12 months of completion of adjuvant endocrine therapy or

* Progressed during prior endocrine therapy for advanced/metastatic disease. Note: 'Progressed during endocrine therapy' means that the patient progressed while on or within 1 month after discontinuation of endocrine therapy.

One line of chemotherapy for advanced/metastatic disease (regardless of prior adjuvant chemotherapy use) is allowed in addition to endocrine therapy.

Patients must have evidence of disease to be eligible for the study, but measurable disease is not mandatory.

For those patient with measureable disease who will be included in the response assessment, the following criteria must apply:

* X-ray ≥ 20 mm

* Spiral CT scan or physical exam ≥ 10 mm (lymph nodes must be ≥ 15 mm in the short axis)

* Conventional CT scan, MRI ≥ 20 mm

* Measurable lesions must be outside a previous radiotherapy field if they are the sole site of disease, unless disease progression has been documented.

Tumor lesions previously irradiated or subjected to other loco regional therapy will only be deemed measurable if progression at the treated site after completion of therapy is clearly documented.

Eastern Cooperative Oncology Group (ECOG) 0-2.

Adequate organ and bone marrow function as defined by:

* ANC ≥ 1,500/mm3 (1.5 x 109/L)

* Platelets ≥ 100,000/mm3 (100 x 109/L)

* Serum creatinine ≤ 1.5 x ULN or estimated creatinine clearance ≥60 ml/min as calculated using the method standard for the institution;

* Total serum bilirubin ≤ 1.5 x ULN (\<3 ULN if Gilbert's disease).

Patient must agree to provide tumour tissue from the most recent pathological tumour specimen.

Patient is able (i.e. sufficiently fluent) and willing to complete the quality of life questionnaires in either English or French

Patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements. Each patient must sign a consent form prior to enrollment in the trial to document their willingness to participate

Patients must be accessible for treatment and follow up. Patients registered on this trial must be treated and followed at the participating centre. This implies there must be reasonable geographical limits placed on patients being considered for this trial.

In accordance with NCIC CTG policy, protocol treatment is to begin within 2 working days of patient randomization.

Women of childbearing potential must have agreed to use a highly effective contraceptive method.

What this study is about