Lead Sponsor

Hospices Civils de Lyon

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Age ≥ 18 years old
•Heart transplantation since 5 months (+/- 3 weeks)
•Stable allograft function :
•* Left ventricular ejection fraction ≥ 50% measured by echocardiography
•* No sign of the presence of humoral rejection or DSA (donor-specific antibodies)
•* Absence of biopsy-proven or treated acute cellular rejection in the previous 3 months
•Signed consent to participate in the study
•Patient affiliated to a social security scheme or similar

•All symptoms or clinical signs of graft failure
•Treatment of a transplant rejection with ISHLT grade 2R or higher (proven by biopsy) during the previous 3 months
•Change of immunosuppressive molecule in the previous 30 days
•Treatment with hematopoietic growth factors in progress or during the previous 30 days
•Corticosteroid dose \> 20 mg / day prednisone equivalent at the time of inclusion
•Transfusion during the previous 30 days
•End-stage renal failure requiring renal replacement therapy (hemodialysis or peritoneal dialysis)
•Pregnant woman at the time of inclusion
•Major patient protected by law