To Evaluate Safety, Pharmacokinetics and Pharmacodynamics of MEDI6012 in Subjects With Stable Coronary Artery Disease

Exclusion Criteria

• •Severe angina pectoris symptoms
• •High-risk coronary or carotid artery disease that will likely require surgical or percutaneous intervention during the study period
• •Hospitalization for heart failure within 12 months prior to screening
• •Uncontrolled Hypertension
• •Within 6 months prior to screening, a history of ACS or hospitalization for heart failure
• •Clinically significant abnormalities in rhythm, conduction or morphology of ECG
• •Subjects with transplanted heart, left ventricular assist device, implanted pacemaker, implantable cardioverter defibrillator, or cardiac resynchronization therapy
• •Untreated life-threatening ventricular arrhythmias
• •History, within 12 months prior to screening, of myocarditis or restrictive pericarditis, or hemodynamically significant valvular hear disease or aortic disease
• •Undergone major surgery with in 3 months prior to screening or has planned major surgery during the study period