Children 6 months to 17 years of age admitted to the hospital because of infected VPS (ventriculitis) will be eligible for the study. A total of twelve eligible patients will be included in the study. Eligible study subjects would be patients who have undergone VPS removal and placement of EVD tubing and are being treated with standard IV antibiotics for ventriculitis. CSF cultures are obtained before antibiotics treatment is initiated. Standard initial antibiotics regimen is usually IV ceftriaxone and vancomycin. The antibiotics regimen is subsequently adjusted based on the pathogen recovered from the CSF culture. Total IV antibiotic treatment is usually 14 days. Following clearance of the infection the patient undergoes new VPS insertion by neurosurgery service.
Age
0–17
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 6 months - 17 years
Ventriculitis due to VPS infection (abnormal CSF parameters consistent with meningeal inflammation and/or positive CSF culture)
VPS is externalized and External Ventriculostomy Drain (EVD) is in place
Patient has IV access and is receiving antibiotic treatment for VPS infection
Parent/Guardian signed written informed consent
Negative urine or serum pregnancy test for females of child-bearing potential
You may not be if
Known Allergy to beta-lactam antibiotics
Moderate to severe renal impairment (Creatinine clearance \< 50mL/minute)
Parent/Guardian written consent cannot be obtained
Positive urine or serum pregnancy test
Clareo Health | Ceftaroline Diffusion Into Cerebrospinal Fluid of Children
