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The Use of Microneedles to Expedite Treatment Time in Photodynamic Therapy | Clinical Trials | Clareo Health

COMPLETEDNA

The Use of Microneedles to Expedite Treatment Time in Photodynamic Therapy

NCT02594644•University of California, Davis

Summary

The aim of this study is to investigate how varying incubation periods of topical aminolevulinic acid after pretreatment with microneedle application can facilitate the penetration and efficacy of photodynamic therapy.

Detailed Description

The current standard of care of photodynamic therapy to treat actinic keratoses includes pre-treatment of the area with topical aminolevulinic acid for 1 hour, followed by treatment with blue light. In a previous study, the investigators showed pretreatment of microneedles enhance penetration of topical aminolevulinic acid as compared to the control group. The aim of this study is to investigate how varying incubation periods of topical aminolevulinic acid after pretreatment with microneedle application can facilitate the penetration and efficacy of photodynamic therapy.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•18 years of age and older
•Subjects has actinic keratoses and qualifies for photodynamic therapy

Exclusion Criteria

•Subjects who smoke
•Subjects who have a photosensitizing condition such as lupus, porphyria, or similar condition
•Subjects who have established allergy to topical ALA
•Subjects who have had a documented nonmelanoma skin cancer on the face over the past 6 months

Locations (1)

University of California-Davis, Department of Dermatology

Sacramento, California, United States

Key Dates

Start Date

November 6, 2014

Primary Completion Date

June 22, 2016

Completion Date

June 22, 2016

Last Updated

November 29, 2018

Enrollment

ACTUAL participants

Conditions

Keratosis, Actinic

Interventions

Microneedle Roller

DEVICE

Aminolevulinic Acid

DRUG

Blue Light

RADIATION

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 29, 2018Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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