The Registration Program of BRCA1/2 Gene

Inclusion Criteria

• •Chinese Genetic/Familial breast cancer patients, and its first or second degree relatives with breast cancer (female or male).
• •The selection will be based on NCCN Clinical Practice Guidelines in Oncology (Genetic/Familial High-Risk Assessment: Breast and Ovarian).
• •Patients: it must be from independent family and meet the one or more of the following conditions.
• •1. Patients' age at diagnosis: 45 years or younger.
• •2. Patients' age at diagnosis: 50 years or younger.
• •3. Breast cancer patients: it must meet the one or more of the following family medical histories.
• •3.1 Patients' age at diagnosis: 50 years or younger, and the one or more of the next of Kin has breast cancer.
• •3.2 Patients' age at diagnosis: any of age, and the one or more of the next of Kin has breast cancer that its age at diagnosis was 50 years or younger.
• •3.3 Patients' age at diagnosis: any of age, and the two or more of the next of Kin have breast cancer that its age at diagnosis was 50 years or younger.
• •3.4 Patients' age at diagnosis: any of age, and the one or more of the next of Kin has epithelial ovarian cancer.
• •3.5 Patients' age at diagnosis: any of age, and the two or more of the next of Kin have pancreatic cancer and/or prostate cancer (Gleason grading\>7, any of age).
• •3.6 Patients' age at diagnosis: any of age, and the one or more of the close-male relatives has breast cancer.
• •4. Triple negative patients' age of onset: 60 years or younger.
• •5. Patients: male and have breast cancer.
• •Patients' first or second degree relatives are BRCA1/2 mutation carrier (1-5 people):
• •First or second degree female adult relatives of patients (age: 18 years or older), it will be selected from the same paternal or maternal side according to the family disease.
• •First or second degree male relatives of patients have breast cancer.