MetAbolism vaRiability of VEnLafaxine

Inclusion Criteria

• •Patient (Hospitalized or outpatient) with major depressive disorder and MADRS ≥ 20 at visit of selection
• •Patients non responders to V after 4 weeks of V at 150mg or less
• •Decision of the psychiatrist to increase the dose of V at visit of selection
• •Understanding of French language and able to give a written inform consent.
• •Informed consent signed to participate to the study
• •Individuals covered by social security regimen