1. Non invasive ventilation

2. Saturation by pulse oxymetry \<88%

3. Documented history of asthma

4. Instable cardiac disease within 6 months.

5. Known long corrected QT interval (QTC) syndrome

6. Known estimated Glomerular Filtration Rate (EGFR) ( \<30 ml/min \*1,73m2

7. Exacerbations of COPD or change of medication for COPD in the last 6 weeks prior to inclusion

8. Allergic reaction or intolerance for a substance used in one of the products or atropine or atropine derived substances

9. Pregnant or lactating females.

Single Dose Ultibro Breezhaler by Sd-DPI Versus Ipratropium/Salbutamol by Nebulizer in COPD