Antiviral Pharmacology and Adherence in Drug Users

Exclusion Criteria

• •Glomerular filtration rate \< 30 mL/min/1.73 m2
• •Receipt of prior HCV treatment and radiographic, histologic, or clinical evidence of cirrhosis
• •Decompensated liver disease (i.e., ascites, history of esophageal variceal bleeding, hepatic encephalopathy)
• •Medications not recommended per the SOF/LDV prescribing information (e.g., tipranavir and other P-gp inducers, tenofovir disoproxil fumarate plus cobicistat, rosuvastatin, amiodarone)
• •Any medical condition that in the opinion of the investigators will make it challenging to adhere to the study protocol, such as unstable heart disease or cancer
• •Chronic Hepatitis B virus Infection
• •For females, active pregnancy or any intent to become pregnant
• •For both sexes, an unwillingness to use contraception during the study period
• •On parole or impending sentencing