Previous cytotoxic chemotherapy or immunotherapy for advanced or metastatic disease

Central nervous system and bone metastases

Moderate or severe renal impairment

Clinically significant cardiac disease

Lack of physical integrity of the upper gastrointestinal tract, malabsorption syndrome, or inability to take oral medication

Malignancy within the last 5 years, except cured basal cell cancer of skin and cured cancer in situ of uterine cervix

A Study of Capecitabine (Xeloda) in Patients With Metastatic Colorectal Cancer