A Study to Evaluate Safety and Efficacy of Lebrikizumab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Exclusion Criteria

• •History of severe allergic reaction or anaphylactic reaction to biologic agent or known hypersensitivity to lebrikizumab injection
• •History of clinically significant pulmonary disease other than COPD
• •Diagnosis of alpha-1-antitrypsin deficiency
• •Lung volume reduction surgery or procedure within 12 months prior to Visit 1
• •Supplemental oxygen requirement \>2 liters/minute (L/min) at rest or with exertion
• •Current diagnosis of asthma
• •Participants participating in, or scheduled for, an intensive COPD rehabilitation program
• •Maintenance oral corticosteroid therapy
• •Treatment with systemic corticosteroids within 4 weeks prior to Visit 1 or during screen period
• •Unstable ischemic heart disease or other relevant cardiovascular disorders
• •Use of an immunomodulatory or immunosuppressive therapy including monoclonal antibodies (includes anti-interleukin-13 (IL) or anti-IL-4/IL-13 therapy)
• •Body weight \<40 kg
• •Any infection that resulted in hospital admission for \>/= 24 hours and/or treatment with oral, intravenous (IV), or intramuscular (IM) antibiotics within 4 weeks prior to Visit 1 or during screening
• •Upper or lower respiratory tract infection within 4 weeks prior to Visit 1 or during screening
• •Active parasitic or Listeria monocytogenes infection within 6 months prior to Visit 1 or during screening
• •Received a live attenuated vaccine within 4 weeks prior to Visit 1 or during screening
• •Active tuberculosis requiring treatment within 12 months prior to Visit 1
• •Human immunodeficiency virus (HIV) or other known immunodeficiency
• •Hepatitis or known liver cirrhosis
• •Aspartate Aminotransferase (AST), Alanine Aminotransferase (ATL), or total bilirubin elevation \>/=2.0 x upper limit of normal (ULN) during screening
• •Clinically significant abnormality on screening electrocardiogram (ECG) or laboratory tests
• •History of alcohol or drug abuse
• •Pregnant or lactating