Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Nxera Pharma UK Limited
With
P1vital Limited
Age
65–80
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Healthy on the basis of medical history, physical examination, vital signs, 12-lead ECG, haematology, blood chemistry, urinalysis and a pre-study psychological assessment.
Mini Mental State Examination (MMSE) Score of ≥24.
Intermediate or extensive metaboliser as determined by CYP2D6 genotype.
Fluent English speaker.
Right-handed.
Not a regular smoker
You may not be if
Recreational drug use within 3 months prior to Screening Visit.
Positive alcohol breath test.
Positive urine drug screen.
Consumption of large amounts of caffeinated drinks.
Consumption of any food or any drinks containing cranberry, pomegranate, star fruit, grapefruit, pomelos, exotic citrus fruits or Seville oranges.
Ultra-rapid or poor metabolizer as determined by CYP2D6 genotype.
By self-report, taking two or more daytime naps per week which in the opinion of the investigator is likely to interfere with the ability of the subject to complete the study procedures.
History of, or presents (in the opinion of the Investigator) with, significant neurological or psychiatric conditions.
Personal or family history of congenital long QT syndrome or sudden death.
Concomitant use of drugs that are metabolised by and/or are inhibitors of CYP2D6.
Concomitant use of drugs that are substrates for the organic cation transporter 2.
History of significant claustrophobia.
Fulfils any of the MRI contraindications on the standard site radiography screening questionnaire (e.g. history of surgery involving metal implants).
