Glutamatergic Modulation of Disordered Alcohol Use

Exclusion Criteria

• •Meets criteria for current major depression, bipolar disorder, schizophrenia, any psychotic illness, including substance induced psychosis, and current substance-induced mood disorder.
• •Physiological dependence on another substance requiring medical management, such as opiods or benzodiazepines, excluding caffeine, nicotine, and cannabis
• •Delirium, Dementia, Amnesia, Cognitive Disorders, or Dissociative disorders. Significant dissociative symptoms
• •Current suicide risk or a history of suicide attempt within the past year
• •Inability to safely initiate 24 hours of abstinence from alcohol; repeated inability to initiate abstinence during the trial without incurring significant withdrawal; history of severe withdrawal phenomena over the past 6 months (e.g., withdrawal-related seizure); or self-reported inability to maintain abstinence for 24 hours without substantial distress.
• •Pregnant or interested in becoming pregnant during the study period
• •Any of the following cardiac conditions: clinically significant left ventricular hypertrophy, angina, clinically significant arrhythmia, or mitral valve prolapse
• •Unstable physical disorders which might make participation hazardous such as end-stage AIDS, hypertension (\>140/90), leukopenia, active hepatitis or other liver disease with elevated transaminase levels (\< 2-3 X upper limit of normal will be considered acceptable if clotting factors are normal), renal failure, epilepsy, or untreated diabetes
• •Previous history of study medication misuse or abuse, and a history of an adverse reaction/experience with prior exposure to study medications
• •Recent history of significant violence (past 2 years)
• •First degree relative with a psychotic disorder (bipolar disorder, schizophrenia, schizoaffective disorder, or psychosis NOS)
• •obesity
• •On psychotropic or other medications whose effect could be disrupted by participation in the study
• •BMI \> 35