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Comparative Volumetric Assessment of Alveolar Ridge Preservation Utilizing Different Bone Grafting Materials | Clinical Trials | Clareo Health

TERMINATEDNA

Comparative Volumetric Assessment of Alveolar Ridge Preservation Utilizing Different Bone Grafting Materials

Prospective, Comparative Volumetric Assessment of Alveolar Ridge Preservation Utilizing Different Bone Grafting Materials (SYMBIOS CORTICAL-CANCELLOUS GRANULE MIX; SYMBIOS OSTEOGRAF LD-300; OSTEOGRAF/N-300) Following Tooth Extraction

NCT02532543•University of North Carolina, Chapel Hill

View on ClinicalTrials.gov

Summary

This study is intended to provide statistically robust evidence that Symbios Demineralized Cortical-cancellous granule mix, Symbios OsteoGraf LD-300, and OsteoGraf/N-300 combined with Symbios OsteoShield Collagen Resorbable Membrane can adequately support the alveolus during ridge augmentation procedures, reducing the dimensional changes of both the alveolus and the overlying soft tissues. Additionally, a comparison between each material will be made, providing further evidence of each materials' ability to preserve the alveolus. It is intended to define in objective terms the response of the hard and soft tissues to ridge augmentation.

Eligibility

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Provision of informed consent
•2. ≥ 18 years and ≤ 75 years
•3. Good physical health (ASAI/II)
•4. Extraction of maxillary premolar, canine or incisor, or mandibular premolar and canine required
•5. Teeth adjacent (mesial and distal) to study site must consist of two stable natural teeth with minimal restorations, without signs of periodontal bone loss (\> 3 mm) and/or significant soft tissue deficiencies

Exclusion Criteria

•1. Buccal plate dehiscence and/or fenestration \>3mm at study site following extraction
•2. Untreated rampant caries and uncontrolled periodontal disease
•3. Inadequate oral hygiene (estimated plaque score \>20%)
•4. Smokers using more than 10 cigarettes or equivalent per day
•5. Smokeless tobacco use or e-cigarette use
•6. Compromised physical health and/or uncontrolled or severe systemic diseases including:
•ASA III/IV Metabolic bone disease History of malignancy History or radiotherapy or chemotherapy for malignancy in the past 5 years History of autoimmune disease Long-term steroidal or antibiotic therapy Uncontrolled diabetes Known alcohol or drug abuse
•7. Systemic or local disease or condition that would compromise post-operative healing
•8. Use of any substance or medication that will influence bone metabolism
•9. Known pregnancy
+4 more criteria

Locations (1)

University of North Carolina School of Dentistry

Chapel Hill, North Carolina, United States

Key Dates

Start Date

April 1, 2016

Primary Completion Date

February 12, 2018

Completion Date

February 12, 2018

Last Updated

December 9, 2019

Enrollment

ACTUAL participants

Conditions

Tooth FracturesTooth InjuriesTooth Diseases

Interventions

Allograft, Membrane

BIOLOGICAL

Alloplast, Membrane

BIOLOGICAL

Xenograft, Membrane

BIOLOGICAL

Membrane

BIOLOGICAL

Clinical Comparison of Different Flowable Resin Composites

NCT04324008

Tooth Diseases

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ACTIVE_NOT_RECRUITINGNA

Evaluation and Treatment of Crown Fractures Using the Modified Baysal Dental Trauma Index

NCT07131462

Dental TraumaCrown Fractures+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 9, 2019Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Comparative Volumetric Assessment of Alveolar Ridge Preservation Utilizing Different Bone Grafting Materials

Inclusion Criteria

Exclusion Criteria

Clinical Comparison of Different Flowable Resin Composites

Evaluation and Treatment of Crown Fractures Using the Modified Baysal Dental Trauma Index

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