Histologically-confirmed breast cancer - based upon pathology report of the primary or metastatic diagnosis

Recurrent breast cancer (local, regional, or distant disease) - as determined by either clinical,radiological, or pathological evaluation

Willing to undergo or provide tissue from a recent biopsy of recurrent tumor for both clinical and research testing

Willing to undergo blood specimen collection

Age 18 or over and are able to give informed consent

Breast Cancer 2-PREVENT Translational Center of Excellence (TCE) - Metastatic Markers of Recurrent Tumor Phenotype for Breast Cancer