Lead Sponsor

Gustave Roussy, Cancer Campus, Grand Paris

Collaborators

Age

18 - No limit years

Sex

FEMALE

Healthy Volunteers

No

•Women who have had a recent diagnosis of atypical breast lesions (atypical metaplasia, atypical ductal hyperplasia, atypical lobular hyperplasia, lobular carcinoma in situ) on a breast biopsy for microcalcifications on mammography Or for little suspect distortion in ultrasound or mammary MRI.
•Report of the anatomopathological examination of the biopsy allowing the diagnosis of an atypical lesion available
•Patient 18 years or more
•Informed consent signed.
•Patient affiliated to a system of social security or beneficiary of such plan
•General condition ECOG-OMS 0 or 1

•Nodular lesion associated with ultrasound or mammography opacity
•Palpable nodule
•Presence of ductal carcinoma in situ or invasive carcinoma associated to biopsy
•Personal history of breast cancer or homo contralateral
•Previous history of breast irradiation or breast cancer or other area for malignancy (Hodgkin, etc ...)
•Women with a BRCA1 or BRCA2 mutation diagnosed or other genetic predisposition to breast cancer and highly penetrant autosomal dominant.
•Pregnant or nursing women
•Women with a cons-indication or refusal of surgery
•Private Women of freedom under guardianship.
•Presence of aggressive lobular in situ carcinoma (pléioforme, Florida or necrosis)