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COMPLETEDPhase 1NCT02521376

Pharmacokinetics of Entospletinib in Adults With Normal and Impaired Liver Function

The primary objective of this study is to evaluate the pharmacokinetics of entospletinib (ENTO) and/or its metabolites (if applicable) in participants with impaired hepatic function (stratified by smo...

Lead sponsor: Gilead Sciences•4 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Gilead Sciences

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Calculated body mass index from 18 to 40 kg/m\^2
•Not pregnant
•Normal electrocardiogram
•Participants with impaired liver function must be sufficiently healthy based upon medical history and physical examination, vital signs, and screening laboratory evaluations.

Exclusion Criteria

•Participation in another clinical study (current or within last 30 days)
•HIV, hepatitis B virus, or active hepatitis C virus infection

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: July 26, 2019Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE1

Enrollment56

Start dateNov 2015

Last updatedJul 26, 2019

Condition

Locations shown

Clinical Pharmacology of Miami, Inc. (CPMI)

Miami, Florida

Orlando Clinical Research Center

Orlando, Florida

DaVita Clinical Research

Minneapolis, Minnesota

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 26, 2019Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions