the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Ankle

Exclusion Criteria

• •1. If patients or their families suffer from or have ever suffered from an autoimmune disease.
• •2. Patients who have ever suffered an anaphylactic reaction.
• •3. Patients who have ever suffered hypersensitivity to an implant.
• •4. Patients with a history of allergy to porcine or bovine protein.
• •5. Subjects with inflammatory arthritis, such as rheumatoid and gouty arthritis.
• •6. Subjects with autoimmune disease related arthritis.
• •7. Subjects who are pregnant and/or breast-feeding and/or plan a pregnancy.
• •8. Subjects with tumors.
• •9. Subjects who have undergone radiotherapy or chemotherapy within the last 2 years (Exception: if the possibility of collagen treatment is confirmed with doctor's clinical decision).
• •10. Subjects who are diabetic. (Exception: if the possibility of CartiFill™ treatment is confirmed with doctor's clinical decision, and/or patient's blood glucose level remains within the normal range and/or no other complications by diabetes mellitus.)
• •11. Subjects with infections, currently on treatment with antibiotics or antimicrobials (Exception: if the possibility of collagen treatment is confirmed with doctor's clinical decision).
• •12. Subjects under adrenocorticoid therapy (Exception: if the possibility of collagen treatment is confirmed with doctor's clinical decision).
• •13. Subjects with psychiatric disorders who are considered inappropriate to participate in this trial by the Principal Investigator.
• •14. Patients who have ever suffered contraindications of the used Fibrin sealant. (The major contraindications are as follows: patients with hypersensitivity to aprotinin and those treatments for severe brisk arterial or venous bleeding.)