Continuous Alloreactive T Cell Depletion and Regulatory T Cell Expansion for the Treatment of Steroid-refractory or Dependent Chronic GVHD

Inclusion Criteria

• •1\. Newly diagnosed chronic GVHD as defined by the National Institutes of Health (NIH) Consensus with no more than 24 weeks of treatment with systemic steroids.
• •AND 2. Chronic GVHD must be refractory or dependent to standard therapy, defined as (one of the following):
• •Progression on prednisone 7 mg/kg/week for 2 weeks, or
• •Stable disease on ≥ 3.5 mg/kg/week of prednisone for 4-8 weeks, or
• •Inability to taper prednisone below 3.5 mg/kg/week.