Efficacy of Lifestyle Intervention in BRCA1/2 Mutation Carriers

Exclusion Criteria

• •current chemotherapy of radiotherapy (inclusion 6 weeks after CTX or RX possible)
• •metastatic tumor disease
• •life expectancy \<3 years
• •clinically limiting cardiovascular or respiratory disease (instable CVD, heart failure stage IV, COPD GOLD IV, maximum resting blood pressure 160/100 mmHg)
• •significant orthopedic disability which prevents from participating in the group interventions
• •severe concomitant diseases which prevents from participating in the group interventions
• •Karnofsky index \<60
• •maximum exercise capacity \<50 W
• •food allergies which prevent from mediterranean diet
• •vegan diet
• •body mass index \<15 kg/m2
• •pregnancy
• •insufficient knowledge of German language
• •insufficient compliance
• •active participation in other interventional trials