Study to Determine the Amount of Glycopyrrolate Absorbed in the Lungs After Taking the Medicine With a eFlow Nebulizer and Seebri® Breezhaler® With and Without Activated Charcoal in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).

1. Severe comorbidities including unstable cardiac or pulmonary disease or any other medical conditions that would, in the opinion of the Investigator, preclude the subject from safely completing the required tests or the study, or is likely to result in disease progression that would require withdrawal of the subject, included but not limited to the following:

* Unstable ischemic heart disease (diagnosis of myocardial infarction or admission for acute coronary syndrome) within 6 months of screening.

* Unstable cardiac arrhythmia or heart failure (change in treatment plan) within 6 months.

* Treatment for diabetes mellitus within 6 months of screening.

2. Current evidence or history of a clinically significant abnormality of cardiac rhythm and/or conduction findings.

3. Concomitant clinically significant respiratory disease other than COPD (eg, asthma, tuberculosis, bronchiectasis, or other non-specific pulmonary disease).

4. History of malignancy of any organ system treated or untreated within the past 5 years, with the exception of localized basal cell carcinoma of the skin.

5. Recent history of COPD exacerbation requiring hospitalization or need for increased treatments for COPD within 6 weeks prior to the Screening Period.

6. Use of daily oxygen therapy \> 10 hours per day.

7. Use of oral, intravenous, or intramuscular steroids within 3 months prior to the Screening Period.

8. Respiratory tract infection within 6 weeks prior to or during the Screening Period.

9. Significant blood loss (\> 500 mL) or donated blood within 60 days preceding screening or plans to donate blood within 60 days after completing the study.

10. History of or clinically significant ongoing bladder outflow obstruction or history of catheterization for relief of bladder outflow obstruction within the previous 6 months.

11. History of narrow-angle glaucoma.

12. Prolonged QTc interval (\> 450 msec for males and \> 470 msec for females) during the Screening Period, or history of long QT syndrome.

13. Recent documented history (previous 12 months) of substance abuse.

14. .Positive urine drug screen at Visit 1 provided the subject is unable to produce a valid medical rationale for the test result (eg, prescription medication).

15. Positive HbsAg, Hepatitis C antibody, or HIV 1/2 antibody test at Screening.

16. History of hypersensitivity or intolerance to aerosol medications, β2-agonists, anticholinergics, or sympathomimetic amines.

17. Significant psychiatric disease that would likely result in the subject not being able to complete the study, in the opinion of the Investigator.

18. Participation in another investigational drug study where drug was received within 30 days prior to the Screening Period, or current participation in another investigational drug trial in which study treatment is being administered, including a SUN-101 study

19. Previously received SUN-101 (active treatment; formerly known as EP-101).

20. Previously received any glycopyrrolate product within 28 days of Screening.

21. Subject is taking theophylline.

What this study is about