Thiotepa-based Conditioning for Allogeneic Stem-cell Transplantation (SCT) in Lymphoid Malignancies

Inclusion Criteria

• •1. Age less than physiologic 68 years.
• •2. Patients with MM, NHL, HL and CLL with an indication for allogeneic transplantation as follows:
• •1. MM; patients relapsing after autologous transplant or with high-risk cytogenetic abnormalities
• •2. Aggressive lymphoma and Hodgkin lymphoma; relapse after autologous transplants
• •3. Follicular lymphoma; failure of at least one prior regimen
• •4. CLL; failure of prior therapy which includes Fludarabine combinations or 17p- cytogenetic abnormality
• •3. Patients must have an HLA matched related or unrelated donor willing to donate either peripheral blood stem cells or bone marrow. Matching is based on high-resolution class I (HLA-A, -B, -C) and class II (HLA-DRB1, -DQB) typing. The goal is to transplant \> 3 x 106 CD34+ cells per kg body weight of the recipient
• •4. Patients must sign written informed consent.
• •5. Adequate birth control in fertile patients.