Prevention of Post-exercise Muscle Fatigue and Effect on Exercise Training in Severe Patients With COPD.

Inclusion Criteria

• •Severe COPD patients in stable condition (Gold class 3 or 4)
• •Ventilatory limitation to exercise during the incremental cardiopulmonary exercise test (at least one of the following criteria) :
• •No breathing reserve
• •Exercise hypoventilation (increase arterial PCO2\> 5 mmHg)
• •Maximal workload \<50 Watts