A Study of [14c]-Samidorphan (Also Known as ALKS 33) in Healthy, Male Volunteers

Exclusion Criteria

• •Clinically significant illness within 30 days
• •History of alcohol or opioid dependence, or positive urine toxicological screen for marijuana, cocaine, amphetamines, opioids, barbiturates, and benzodiazepines
• •History of oral or gastrointestinal disease
• •Irregular bowel or bladder function
• •History of allergy or hypersensitivity to opioid medications or opioid antagonists (eg, naltrexone, naloxone)
• •Current or pending legal charges or probation that would interfere with study conduct
• •Use of alcohol within 24 hours prior to admission or urine positive test for alcohol at screening or admission
• •Tobacco or nicotine use within 90 days
• •Anticipated need for prescription medicines during the study period
• •Additional criteria may apply