About Pricing FAQs Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Back to clinical trial search

UNKNOWNPhase 3NCT02504008

CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1

This is a randomized, double-blind, placebo-controlled, 24-week study to evaluate the efficacy and safety of AXS-02 in patients with CRPS-I.

Lead sponsor: Axsome Therapeutics, Inc.•29 U.S. locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Save this trial guide to your notes

Keep your clinical trial research organized — questions to ask, what to expect, and key details.

Sponsors

Lead Sponsor

Axsome Therapeutics, Inc.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Male or female of at least 18 years of age
•Recently confirmed diagnosis of CRPS-1 (Budapest criteria)
•Average pain intensity score of ≥ 5 (based on an 11-point scale \[0 - 10\])
•Willing and able to provide written informed consent

Exclusion Criteria

•Received chronic opioid therapy within 4 weeks
•Received a sympathetic nerve block within 3 weeks
•Active litigation or a pending workers' compensation decision
•Any other clinically significant medical or pain condition (eg, Parkinson's disease, cognitive impairment, or fibromyalgia) or clinical laboratory abnormality that would in the investigator's judgment interfere with the subject's ability to participate in the study

Related studies

Peripersonal Space Representation in Upper Limb Segmental Exclusion

NCT07349173 · Segmental Exclusion Syndrome, Complex Regional Pain Syndrome (CRPS), and more

Perineural Incobotulinumtoxin-A for Complex Regional Pain Syndrome - An Open-label Feasibility Study

NCT07473635 · CRPS (Complex Regional Pain Syndromes), CRPS (Complex Regional Pain Syndrome) Type I, and more

Infrared Images for Spinal Cord Stimulation in Complex Regional Pain Syndrome Patients

NCT05777889 · Complex Regional Pain Syndromes

Non Invasive Neurostimulation Technology for the Treatment of Type I Complex Regional Pain Syndrome (CRPS I)

NCT05052736 · Type I Complex Regional Pain Syndrome

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

NCT04144972 · Spinal Cord Injuries, Nerve Injury, and more

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 23, 2018Terms

Trial snapshot

StatusUNKNOWN

PhasePHASE3

Enrollment190

Start dateJul 2015

Last updatedMar 23, 2018

Condition

Complex Regional Pain Syndrome Reflex Sympathetic Dystrophy

Locations shown

Tucson, Arizona

Hot Springs, Arkansas

Encinitas, California

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Start free trial →

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 23, 2018Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions