Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response

Exclusion Criteria

• •Significant non-ET related abnormal findings during neurological exam.
• •Presence of a tremor at rest.
• •Pregnant or nursing.
• •Unable to safely undergo MRI based on completion of a safety questionnaire.
• •History of dementia, brain tumor, stroke, head trauma or a vascular malformation based on history or MRI findings.
• •Severe active medical condition, such as cardiovascular disease, that prevents subject from lying flat for up to 120 minutes.
• •Unable or unwilling to provide informed consent.
• •Claustrophobia (a fear of tight spaces) or other restrictions that prevent subject from undergoing an MRI in a confined space for up to 120 minutes.
• •Unable to temporarily stop taking medications that may influence liver metabolism or brain function.
• •Tremors so severe that subject cannot safely and effectively undergo MRI
• •Past/current problems with alcohol abuse or dependence.
• •Unwillingness to take alcohol (ethanol), which is a potentially intoxicating drug
• •History of deep brain stimulation or thalamotomy surgery.
• •Sinus bradycardia, bronchial asthma, or a known allergy to propranolol (Inderal).